AC8221 Hygienic Conductivity Sensor for Biopharmaceutical Purified‑Water & Bioprocess Monitoring

Solution: AC8221 Hygienic Conductivity Sensor

ACITEK supplied AC8221 two‑electrode hygienic conductivity sensors for installation on purified‑water outlet points, buffer preparation skids and CIP return pipelines.

Key sensor features deployed on‑site

• Wetted‑part material: 316L/1.4404 stainless‑steel electrode, FDA‑compliant PEEK armature and EPDM sealing. Electro‑polished surface Ra < 0.4 µm for clamp‑version, minimizing residue accumulation.
• Built‑in Pt1000 temperature sensor: delivers real‑time temperature compensation for accurate conductivity readings across variable process temperatures.
• Process connections: 1½" sanitary clamp for purified‑water loop installation; ¾ NPT thread for buffer tank side‑port mounting. Electrical interface: 4‑pin M12 male connector with IP67 protection grade.
• Wide operating envelope: fluid temperature‑20 °C ~ +150 °C; pressure PN16 below 120 °C, PN10 at 150 °C. Fully compatible with CIP chemical washing and SIP steam sterilization.
• Compliance: FDA declaration and USP Class VI certification for wetted components, supporting GMP audit documentation.
• System matching: paired with ACITEK G300 transmitter for inline data acquisition and plant‑PLC interconnection.

On‑site Implementation

Multiple AC8221 sensors were installed at critical monitoring points:

1. Purified‑water distribution loop outlets: continuously track water quality to meet pharmacopoeia conductivity specifications.
2. Buffer make‑up station: monitor conductivity of biological buffer solutions before feeding into bioreactors.
3. CIP return pipeline: judge rinse‑end‑point by conductivity shift after acid‑alkali cleaning cycles.

Installation adopted sanitary clamp connections for fast disassembly during periodic calibration. M12 cable connectors guaranteed stable signal under humid clean‑room environment. Sensors went through multiple SIP steam‑sterilization cycles up to 150 °C as part of regular production routines.

Project Results & Customer Benefits

1. Stable & accurate measurement: Relative linearity within ±0.5 ~ 5 % for pure‑liquid measurement; temperature compensation by integrated Pt1000 eliminated manual correction errors. Readings remain consistent after dozens of CIP/SIP cycles.
2. Hygiene compliance: Electro‑polished crevice‑free surface, FDA and USP Class VI material certificates fully satisfy biopharma GMP audit requirements. No microbial‑growth risk on wetted surfaces.
3. Reduced maintenance & downtime: Robust construction tolerates repeated high‑temperature sterilization. Sensor service life extended, cutting replacement frequency versus previous probes.
4. Flexible integration: Dual available process‑connection options fit both pipeline loop and tank mounting; IP67‑rated M12 connector adapts to clean‑room installation conditions, seamlessly working with existing G300 transmitter system.
5. Process reliability: Real‑time inline conductivity data replaces partial manual lab sampling, providing continuous traceable records for batch‑release and regulatory inspection.

Conclusion

The AC8221 hygienic two‑electrode conductivity sensor is a reliable solution for pharmaceutical and biotech hygienic processes targeting pure‑liquid and ultrapure‑water measurement. With sterilization resistance, hygienic material certification and flexible process connections, it delivers stable inline conductivity monitoring for purified‑water systems, buffer preparation and CIP‑cycle control in GMP‑regulated production environments.

Contact

Shanghai Guizhen Instrument and Equipment Co., Ltd. Attn: Jane Zhou E‑mail: jane.zhou@acitekinst.com TEL: +0086 15900873433 WhatsApp: +86 177 0847 1954 Website: www.acitekinst.com